Cover of: Aging of the Genome | Jan Vijg

Aging of the Genome

The Dual Role of DNA in Life and Death
  • 384 Pages
  • 4.24 MB
  • 5718 Downloads
  • English
by
Oxford University Press, USA
The Physical Object
ID Numbers
Open LibraryOL7401166M
ISBN 10019856922X
ISBN 139780198569220

Aging of the Genome: The Dual Role of DNA in Life and Death 1st Edition by Jan Vijg (Author)Cited by: This book"The Age of Genomes" tales from the front lines of genetic medicine which is a relative new concept is a very interesting read.I found that this world of DNA and what it represents is astounding and fascinating start to what could be both positive and negative in the world compared to the nuclear physics of the last century/5.

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences.

This book critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology.

The Genetics of Aging is divided into several sections in an attempt to provide a logical progression from the level of the genome to the realm of human genetics. The relationship between the genetic material and aging will be thoroughly explored in the initial chapters.5/5(1).

Although fantastically complicated in its details, the underlying issue is relatively simple to understand and therefore to fix (in theory).

Description Aging of the Genome PDF

The easiest way to understand the problem is by comparing single-celled organisms to cancerous human ce. Buy Aging of the Genome: The Dual Role of DNA in Life and Death 1 by Vijg, Jan (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders.5/5(1).

Researcher Jan Vijg's profile at the Buck Institute for Age Research includes a link to the first chapter of his recent book, "Aging of the Genome" in PDF stands in the school that believes stochastic corruption of the genome is at the root of aging.

Instability of the genome has been considered as a possible cause of aging since the late 's, when it was discovered that low. For Genome by Matt Ridley. Chromosome 1: Life. Ridley begins the chapter with a parody of the beginning of the Biblical book of Genesis, with “In the beginning was the word ” and later reveals that the “word” is RNA, not DNA.

Genome maintenance, longevity assurance pathway. In the quest of human longevity genes, genes Aging of the Genome book in the conserved pathways of aging have been popular candidates as they were shown to significantly impact healthspan and lifespan in model organisms across a great evolutionary by: 4.

Genome: The Autobiography of a Species in 23 Chapters is a popular science book by the science writer Matt Ridley, published by Fourth chapters are numbered for the pairs of human chromosomes, one pair being the X and Y sex chromosomes, so the numbering goes up to The book was welcomed by critics in journals such as Nature and newspapers including The New York Author: Matt Ridley.

Genome instability plays a significant role in the progression of aging and protecting our aging genomes is therefore of fundamental importance for healthy aging. A major issue for the development of interventions targeting aging is the long trial time and difficulty in determining positive outcomes (see Outstanding Questions).Cited by: 1.

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its Range: $ - $ Aging of the Genome: the dual role of DNA in life and death: Vijg, Jan: Books - 5/5(1).

Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging.

To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect4/5. The Genetics of Aging is divided into several sections in an attempt to provide a logical progression from the level of the genome to the realm of human genetics.

The relationship between the genetic material and aging will be thoroughly explored in the initial chapters. The phenotypes used in studies of the genetics of human aging are usually lifespan (age at death), longevity (long life, usually defined as being a specific advanced age or older at the time of study), exceptional longevity (defined as attaining or exceeding a specific exceptional age), or healthy aging (a combination of old age and health, often defined as freedom from specific disorders or Cited by: Genetic Theory of Aging The genetic theory of aging states that lifespan is largely determined by the genes we inherit.

According to the theory, our longevity is primarily determined at the moment of conception and is largely reliant on our parents and their genes.

Download Aging of the Genome EPUB

Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral.

main genome, so 20 years ago scientists began looking at the idea of putting copies of the 13 genes of interest into the nucleus after making modifications that.

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. This book reviews the concept of genomic instability as a.

Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging.

To enhance gerontology’s focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral.

Aging of the Genome by Jan Vijg,available at Book Depository with free delivery worldwide/5(5). This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.

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Aging of the genome [electronic resource]: the dual role of DNA in life and death / Jan Vijg. Main author: Vijg, Jan.

Corporate Author: Ebook Central Academic Complete., ProQuest (Firm) Format: eBook Online access: Connect to electronic book via Ebook Central. Books. Aging of the Genome, The dual role of DNA in life and death. Vijg, Jan. Oxford University Press: ISBN The American Technological Challenge, Stagnation and Decline in the 21st Century.

Vijg, Jan. Algora Publishing: ISBN Find many great new & used options and get the best deals for Aging of the Genome: the dual role of DNA in life and d by Vijg, Jan Hardback at the best online prices at. Genetics and genomics of human ageing H.

Wheeler & S. Kim aging: biological age as an alternative to the use of survival S. Genome-wide views of aging gene net.

Turning off 'aging genes' Date: January 2, Source: American Friends of Tel Aviv University Summary: Restricting calorie consumption is one of the few proven ways to combat aging. Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health.

The book expands a number of existing major theories Author: Caleb E. Finch. Get this from a library!

Aging of the genome: the dual role of DNA in life and death. [Jan Vijg] -- Aging has long been ascribed to the gradual accumulation of mutations in the genome.

However, it is only recently that the necessary sophisticated technology has been developed to begin testing this.This book critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms.Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK CHAPTER 9 INTRODUCTION The sequencing of genomes has revolution-ized biological and biomedical research.

Thanks to various technologies and approaches that take advantage of genome sequence knowl-edge, researchers can now focus on.