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Vascular risk factors and neuroprotection in glaucoma

update 1996
  • 248 Pages
  • 2.74 MB
  • English

Kugler Publications , Amsterdam, New York
Glaucoma., Eye -- Blood-vessels., Optic nerve., Retina., Glaucoma -- physiopathology., Glaucoma -- drug therapy., Risk Fac
Statementedited by Stephen M. Drance.
ContributionsDrance, Stephen M.
LC ClassificationsRE871 .V37 1997
The Physical Object
Paginationix, 248 p. :
ID Numbers
Open LibraryOL671664M
ISBN 109062991378
LC Control Number97017662

Therefore, neuroprotection in glaucoma is aimed at protecting those neurons that are damaged or likely to be damaged in glaucomatous optic neuropathy which consists of neurons along the entire visual pathway, chiefly the RGC axons. This Cited by: Get this from a library. Vascular risk factors and neuroprotection in glaucoma: update [Stephen M Drance;].

Vascular dysregulation has been implicated in the pathogenesis of glaucoma, therefore a neuroprotective effect has been suggested for agents which can improve regulation of ocular blood perfusion. Some anti-glaucoma medications have additional ocular blood perfusion effects. The role of vascular risk factors in glaucoma is still being debated.

To assess the importance of vascular risk factors in patients with primary open-angle glaucoma (POAG), data from the medical. Interestingly, systemic Vascular risk factors and neuroprotection in glaucoma book diseases also occur in glaucoma patients and are considered to be vascular risk factors [9] [10][11].

Whether migraine is simply a concomitant condition in. vascular insufficiency in the optic nerve head are only risk factors for the development of glaucoma, and are not the only target f or the treatment of glaucoma. The reason is that the. 5 Aqueous humor outflow pathways 6 Aqueous Humor Dynamics and Intraocular Pressure Elevation 7 Pathogenesis of glaucomatous optic neuropathy 8 Mechanical Strain and Restructuring of the Optic Nerve Head 9 Role of Vascular Blood Flow in the Pathogenesis of Glaucoma Section 3 Evaluation of Glaucoma 10 Tonometry.

Significant risk factors for glaucoma include elevated intraocular pressure, age, race, and family history. A role for family history as a risk factor and potential insight into the molecular pathophysiology of glaucoma is further supported by our understanding of the genetics of Cited by:   Glaucoma is an optic neuropathy, specifically a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons.

The pathogenesis of RGC loss in glaucoma Cited by: That is the excitement of neuroprotection research and, at some future stage we hope, neuroregeneration itself. Now, part of the thrill of treating glaucoma is the feeling that our treatment options—and patients’ prognosis for vision—are on the cusp of changing.

modifiable risk for progression of glaucoma and has been the target for treatment. The pathogenesis of glaucoma was originally based on the mechanical and vascular dysregulation.

Results: The evidence for risk factors of low CSF pressure, IOP, smoking, vascular risk factors and light toxicity is described. Latest diagnostic and monitoring techniques for glaucoma include SD-OCT, DARC and IOP telemetry. Current and emerging medical and surgical treatments in Cited by: 3.

(IOP) and vascular insufficiency in the optic nerve head are merely risk factors for the development of glaucoma. The central role of raised IOP is being questioned as many patients continue to demonstrate a clinically downhill course despite control of initially raised IOP [3].

In addition, up to one-sixth of patients with glaucoma develop it. RGC death and its prevention are the subjects of active neurobiological research. Although IOP lowering is still the mainstay of glaucoma treatment, neuroprotection and possibly neuroregeneration may become possibilities in the future.

Ultimately, RGC loss must be stopped. Risk factors such as elevated IOP, decreased neurotrophin support, glutamate-associated excitotoxicity, hypoperfusion, and vasospasm have been implicated in ganglion cell death in glaucoma.

Neuroprotective strategies have focused on mitigating these risk factors associated with retinal ganglion cell loss in by: 6. [1, 2] It is the leading cause of irreversible blindness worldwide and complex genetic and environmental risk factors have been implicated in its progression.

[ 4 - 7 ] Neuroprotection for glaucoma refers to any intervention that aims either to prevent optic nerve damage and retinal ganglion cell death or to preserve already diseased neuronal Author: Sotiria Palioura, Demetrios G.


Description Vascular risk factors and neuroprotection in glaucoma EPUB

Neuroprotection in the eld of glaucoma is de ned as any treatment, independent of IOP reduction, which prevents RGC death.

Glutamate antagonists, ginkgo biloba extract, neurotrophic factors. Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible for the neurodegenerative damage are not clear.

Undoubtedly, the high intraocular pressure (IOP) and the secondary ischemic and mechanical damage of the optic nerve have a crucial role in retinal ganglion cell (RGC) death. Several studies specifically analyzed the events that lead to nerve fiber layer Cited by: 6. The pathogenesis of glaucoma was originally based on the mechanical and vascular dysregulation theory, however, this has evolved over the past decade.

With the classification of low tension glaucoma, it is now recognized that the damage that occurs in the optic disc is not directly due to the elevated IOP and may be independent of this risk by: 2. Glaucoma: An Open Window to Neurodegeneration and Neuroprotection Edited by Carlo Nucci, Luciano Cerulli, Neville N.

Osborne, Giacinto Bagetta Volume   Clinically, vascular risk factors should be sought mainly in patients with normal intraocular pressure who present progressive visual field defects. The therapeutic aim in glaucoma is to prevent or modify the risk factors, especially the intraocular hypertension by.

PubMed was used to search for terms including glaucoma risk factors, glaucoma diagnostics, glaucoma treatment, glaucoma drug delivery and glaucoma IOP. RESULTS: The evidence for risk factors of low CSF pressure, IOP, smoking, vascular risk factors and light toxicity is described.

Latest diagnostic and monitoring techniques for glaucoma include SD-OCT, DARC and IOP telemetry. Current and Cited by: 3.

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() Endothelium-dependent vasoactive factors in the ophthalmic circulation. in Vascular risk factors and neuroprotection in glaucoma—update. ed Drance SD (Kugler, Amsterdam/New York), pp 15 – ↵Cited by: The different risk factors known lead through the same or similar pathomechanisms to GON.

Therapeutically, we can either eliminate or mitigate risk factors or target defined pathogenic steps. Risk factors that can be influenced include increased IOP, low blood pressure, and vascular by:   Glaucoma in the 21st century is a complex group of diseases with numerous risk factors, ranging from oxidative damage to inflammation to genetic disorders to mitochondrial dysfunction—all of which can lead to apoptosis and glaucomatous disc damage.

increased IOP and/or other risk factors reducing ocular blood flow. Over the last few years, there has been mount-ing evidence in the literature on the possible role in glaucoma played by the ocular vascular system, associated vas-cular cellular mediators, and factors other than IOP.

The general consensus is that various contributing risk factorsFile Size: 82KB. The most significant recent advances in the pathogenesis and treatment of NTG will be discussed in the present review. Advance in the Pathogenesis of Normal-Tension Glaucoma Vascular and Mechanical FactorsCited by: Yet, definite sets are at advanced risk when compared to others.

There are most important risk factors apart from elevated IOP which lead to the formation of glaucoma such as myopia, hypertension, the central corneal thickness of size less than 5 mm pseudoexfoliation syndrome, larger cup-to-disc ratio and ocular perfusion : Khushwant S.

Yadav, Sushmita Sharma, Vaishali Y. Londhe. Glaucoma shares a number of features with degenerative brain diseases such as Alzheimer’s, Parkinson’s, and Lou Gehrig’s disease. In all of these diseases, age and family history are significant risk factors, and specific areas of the brain are damaged over time.

Book Chapters. Harris A, Evans D, Martin B. “Individual responsiveness to ocular vasodilatation.” In Vascular Risk Factors and Neuroprotection in Glaucoma. Ed Stephen M. Drance. Kugler Publications, New York, pgs Boxer Wachler B, Evans D, Krueger R. “Advanced Visual Function Testing in LASIK.” In LASIK.

Glaucoma is an eye disease that is often associated with elevated intraocular pressure, in which damage to the eye (optic) nerve can lead to loss of vision and even blindness.; Glaucoma is the leading cause of irreversible blindness in the world.

Details Vascular risk factors and neuroprotection in glaucoma FB2

Glaucoma usually causes no symptoms early in its course, at which time it can only be diagnosed by regular eye examinations (screenings with the. Despite the identification of several risk factors for POAG, the main--if not the only--therapeutic target to treat glaucoma still remains the IOP.

Even though clinical studies have shown that decreasing the IOP is necessary, it is not the only condition capable of preventing glaucoma development or progression [4].Other risk factors derived from large prospective cohort studies include increased age, ethnicity, selected medication, myopia, and a thin cornea.

6 Finally, some specific risk factors may be associated with normal- or low-tension glaucoma, such as migraine headaches, disc hemorrhages, vascular dysregulation, and sleep apnea. 7,8 But the.